Validating sexual development test using spined stickleback addressing fish toxicity testing

Page 11. Katsiadaki, I. Validating a sexual development test using the 3- spined stickleback for addressing the 3Rs in fish toxicity testing.
Toxicity Tests with an Emphasis on Developmental, Reproductive and. Endocrine . 141, Report of the Phase 1 of the Validation of the Fish Sexual . country to address the comments from the peer reviewers. .. There were considerable variation in sex ratio in 3- spined stickleback between laboratory 6.
Validating a sexual development test using the 3- spined stickleback for addressing the 3Rs in fish toxicity testing. Lead Research Organisation: Centre for Env.

Validating sexual development test using spined stickleback addressing fish toxicity testing traveling

The fish endocrine system is strikingly similar to that of humans. For more information see our cookie policy. Clear cell adenocarcinoma of the vagina and cervix secondary to intrauterine exposure to diethylstilbestrol. Cellular and molecular effects of developmental exposure to diethylstilbestrol: implications for other environmental estrogens. Jakobsson S, Mayer I, Schulz RW, Blankenstein MA, Borg B. We believed that this concentration would be sufficient to induce spiggin production but would not be so high as to mask any antiandrogenic activity. Furthermore, the species is endemic and ubiquitous in Europe, and it possesses many ecological traits that make it better suited than other potential species for field research into endocrine disruption.




Cellular and molecular mechanisms of action of linuron: an antiandrogenic herbicide that produces reproductive malformations in male rats. Horny corner long beach adenocarcinoma in mice following developmental treatment with oestrogens: a model for hormonal carcinogenesis. NCBI Skip to main. Fenitrothion is an exceptionally potent androgen antagonist in vivo also first evidence in teleosts. This is the mechanism used to extract data from the system using a CSV template. The next step involved in adapting the spiggin bioassay for antiandrogens was to obtain a dose—response curve for FL-induced inhibition of spiggin production. However, the length of the study and the nonwater-borne exposure preclude any comparisons of the sensitivity of the bioassay with the stickleback assay. Subscribe Marketing Packages Forums Cookie Law. Company No part of this site may be reproduced without permission. Please tell us where you heard about GtR. Sections were stained with periodic acid—Schiff. Multiple Organisations listed on a project. Extraretinal photoreception involved in photoperiodic effects on reproduction in male three-spined sticklebacks, Gasterosteus aculeatus. This sensitivity of fish to environmental EDs can therefore be utilised to develop useful tools. Copyright This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original DOI This article has been cited by other articles in PMC. Flutamide FL and its derivatives are the main representatives of the latter category, validating sexual development test using spined stickleback addressing fish toxicity testing, and they have been studied extensively because of their proven clinical efficacy in the treatment of prostate cancer Singh et al. Fish Wild three-spined sticklebacks were obtained with hand nets from U. Effects of in utero exposure to linuron on androgen-dependent reproductive development in the male Crl:CD SD BR rat.



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  • We are conducting a short survey on why and how often Gateway to Research is used. The antiandrogenic activity of FL has been detected in male fathead minnows through a reduction in the number of nuptial tubercles Panter et al. We would value your opinion on how best to improve this service for our users.
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  • Tanks were aerated constantly. This sensitivity of fish to environmental EDs can therefore be utilised to develop useful tools.





Travel: Validating sexual development test using spined stickleback addressing fish toxicity testing

Validating sexual development test using spined stickleback addressing fish toxicity testing Environmental antiandrogens: developmental effects, molecular mechanisms, and clinical implications. Cellular and molecular mechanisms of action of linuron: an antiandrogenic herbicide that produces reproductive malformations in male rats. Effects of the mammalian antiandrogen vinclozolin on development and reproduction of the fathead minnow Pimephales promelas Aquat Toxicol. The enzyme-linked immunosorbent assay ELISA procedure for spiggin has been described in detail elsewhere Katsiadaki et al. The fish endocrine system is strikingly similar to that of humans.
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